As filed with the Securities and Exchange Commission on June 15, 1999
                            Registration No. 33-


                     SECURITIES AND EXCHANGE COMMISSION
                           WASHINGTON, D.C. 20549

                                  FORM S-8

                           REGISTRATION STATEMENT
                                   UNDER
                         THE SECURITIES ACT OF 1933


                      REGENERON PHARMACEUTICALS, INC.
           (Exact name of registrant as specified in its charter)

        NEW YORK                             13-3444607
 (State of incorporation)           (I.R.S. employer identification no.)

                        777 Old Saw Mill River Road
                         Tarrytown, New York 10591
                  (Address of principal executive offices)


                      REGENERON PHARMACEUTICALS, INC.
                       1990 LONG-TERM INCENTIVE PLAN
                          (Full title of the plan)


    Paul Lubetkin, Esq., Vice President, General Counsel, and Secretary
                      Regeneron Pharmaceuticals, Inc.
                        777 Old Saw Mill River Road
                         Tarrytown, New York 10591
                               (914) 347-7000
         (Name, address and telephone number, including area code,
                           of agent for service)


                                 Copies to:

                         David J. Goldschmidt, Esq.
                    Skadden, Arps, Slate, Meagher & Flom
                              919 Third Avenue
                          New York, New York 10022
                               (212) 735-3000



                       CALCULATION OF REGISTRATION FEE



==============================================================================================================
                                              Proposed Maximum          Proposed Maximum      Amount of
Title of Securities     Amount to  be         Offering Price            Aggregate Offering    Registration
to be Registered        Registered            Per Share (1)(2)          Price (2)             Fee
==============================================================================================================

                                                                                    
Common Stock,
par value
$0.001 per
share                   1,500,000 shares        $6.75                     $10,125,000           $3,491
===============================================================================================================

(1) Estimated pursuant to paragraphs (c) and (h) of Rule 457 under the
    Securities Act of 1933, as amended, on the basis of the average of the
    high and low sale prices for a share of Common Stock on Nasdaq National
    Market on June 10, 1999, within five business days prior to filing.
(2) Estimated solely for the purpose of calculating the registration fee.





                           REGISTRATION STATEMENT

                                    FOR

                   REGISTRATION OF ADDITIONAL SECURITIES

                                ON FORM S-8



                         Incorporation by Reference

               Hereby incorporated by reference is Registrant's
Registration Statement on Form S-8 (No. 33-50480) filed on August 5, 1992
with the Securities and Exchange Commission (the "Commission") pursuant to
the Securities Exchange Act of 1934, as amended (the "Securities Act").

                Required Information Not in Prior Statement

               Not Applicable.




                                 SIGNATURES


               Pursuant to the requirements of the Securities Act,
Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused
this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Tarrytown, State of New York, on
the 11th day of June, 1999.


                               REGENERON PHARMACEUTICALS, INC.


                               By  /s/ Leonard S. Schleifer, M.D., Ph.D.
                                   ----------------------------------------
                                       Leonard S. Schleifer, M.D., Ph.D.
                                   President and Chief Executive Officer



               KNOW ALL MEN BY THESE PRESENTS, that each person whose
signature appears below constitutes and appoints Paul Lubetkin his or her
true and lawful attorney-in-fact and agent, with full power of substitution
and revocation, for him or her and in his or her name, place and stead, in
any and all capacities, to sign any and all amendments (including
post-effective amendments) to this Registration Statement and to file the
same with all exhibits thereto, and other documents in connection
therewith, with the Securities and Exchange Commission, granting unto said
attorneys-in-fact and agents, and each of them, full power and authority to
do and perform each and every act and thing requisite and necessary to be
done as fully to all intents and purposes as he might or could do in
person, hereby ratifying and confirming all that said attorney-in-fact and
agent, or any of his or her substitute or substitutes, may lawfully do or
cause to be done by virtue hereof.

             Pursuant to the requirements of the Securities Act, this
Registration Statement has been signed below by the following persons on
behalf of the Registrant and in the capacities indicated on June 11, 1999.


            Signature                         Title
            ---------                         ------

  /s/ P. Roy Vagelos, M.D.
- -------------------------------         Chairman of the Board of Directors
      P. Roy Vagelos, M.D.


 /s/ Leonard S. Schleifer, M.D., Ph.D.
- -------------------------------------   President, Chief Executive Officer
     Leonard S. Schleifer, M.D., Ph.D.  (Principal Executive Officer), and
                                        Director


 /s/ Murray A. Goldberg
- -------------------------------------   Vice President, Finance &
     Murray A. Goldberg                 Administration, Chief Financial
                                        Officer, and Treasurer
                                        (Principal Financial Officer)


 /s/ Douglas S. McCorkle
- ----------------------------------      Controller and Assistant Treasurer
     Douglas S. McCorkle                (Chief Accounting Officer)


 /s/ Charles A. Baker
- ----------------------------------      Director
     Charles A. Baker


 /s/ Michael S. Brown, M.D.
- ----------------------------------      Director
     Michael S. Brown, M.D.


 /s/ Alfred G. Gilman, M.D., Ph.D.
- --------------------------------------  Director
     Alfred G. Gilman, M.D., Ph.D.


 /s/ Joseph L. Goldstein, M.D.
- -------------------------------------   Director
     Joseph L. Goldstein, M.D.


 /s/ Fred A. Middleton
- ------------------------------------    Director
     Fred A. Middleton


 /s/ Eric M. Shooter, M.D
- -----------------------------------     Director
     Eric M. Shooter, M.D


 /s/ George L. Sing
- ----------------------------------      Director
     George L. Sing




                                 LIST OF EXHIBITS


Designation    Description of Exhibit
- -----------    ----------------------

     4.1       Registrant's Articles of Incorporation (incorporated by
               reference to Registrant's Quarterly Report on Form 10-Q for
               its quarter ended June 30, 1991, filed with the
               Commission on August 13, 1991).

     4.2       Registrant's By-Laws (incorporated by reference to
               Registrant's Annual Report on Form 10-K for its year ended
               December 31, 1994, filed with the Commission on March 31 ,
               1995).

     5         Opinion of Skadden, Arps, Slate, Meagher & Flom.

     23.1      Consent of PricewaterhouseCoopers LLP (for the Registrant).

     23.2      Consent of Ernst & Young LLP (for Amgen-Regeneron Partners).

     23.3      Consent of Skadden, Arps, Slate, Meagher & Flom (contained in
               Exhibit 5).

     24        Power of Attorney (see signature page).



                                                              EXHIBIT 5


                                        June 11, 1999



 Regeneron Pharmaceuticals, Inc.
 777 Old Saw Mill River Road
 Tarrytown, New York  10591

 Gentlemen:

           We have acted as special counsel to Regeneron Pharmaceuticals,
 Inc., a New York corporation (the "Company"), in connection with the
 proposed issuance by the Company of up to 1,500,000 shares (the "Shares")
 of Common Stock, par value $.001 per share (the "Common Stock"), pursuant
 to the Regeneron Pharmaceuticals, Inc. Amended and Restated 1990 Long Term
 Incentive Plan (the "Stock Option Plan").

           This opinion is delivered in accordance with the requirements of
 Item 601(b)(5) of Regulation S-K under the Securities Act of 1933, as
 amended (the "Securities Act").

           In connection with this opinion, we have examined and are
 familiar with originals or copies, certified or otherwise identified to our
 satisfaction, of (i) the Company's Registration Statement on Form S-8,
 relating to the Shares, filed with the Securities and Exchange Commission
 (the "Commission") under the Securities Act on June 11, 1999(together with
 all exhibits thereto, the "Registration Statement"), (ii) the Restated
 Certificate of Incorporation of the Company, as currently in effect, (iii)
 the By-Laws of the Company, as currently in effect, (iv) specimen
 certificates representing the Common Stock, (v) resolutions of the Board of
 Directors of the Company relating to the Stock Option Plan and the filing
 of the Registration Statement; (vi) the Stock Option Plan; and (vii) the
 form of option agreement between the Company and the employees, directors
 and other service providers receiving options (the "Option Agreement").  We
 have also examined originals or copies, certified or otherwise identified
 to our satisfaction, of such records of the Company and such agreements,
 certificates of public officials, certificates of officers or other
 representatives of the Company and others, and such other documents,
 certificates and records, as we have deemed necessary or appropriate as a
 basis for the opinions set forth herein.

           In our examination, we have assumed the legal capacity of all
 natural persons, the genuineness of all signatures, the authenticity of all
 documents submitted to us as originals, the conformity to original
 documents of all documents submitted to us as certified or photostatic
 copies and the authenticity of the originals of such latter documents.  In
 making our examination of documents executed or to be executed by parties
 other than the Company, we have assumed that such parties had the power,
 corporate or other, to enter into and perform all obligations thereunder
 and have also assumed the due authorization by all requisite action,
 corporate or other, and execution and delivery by such parties of such
 documents and the validity and binding effect thereof.  We have further
 assumed that each of the Option Agreements to be entered into between the
 Company and the employees, directors and other service providers receiving
 options under the Stock Option Plan will conform to the form of agreement
 examined by us.  As to any facts material to the opinions expressed herein
 which we have not independently established or verified, we have relied
 upon oral or written statements and representations of officers and other
 representatives of the Company and others.

           Members of our firm are admitted to the Bar in the State of New
 York, and we do not express any opinion as to the laws of any other
 jurisdiction.

           Based upon and subject to the foregoing, we are of the opinion
 that the Shares to be issued upon exercise of any options duly granted
 pursuant to the terms of the Stock Option Plan have been duly and validly
 authorized and, when (i) the Shares have been issued, delivered and paid
 for upon exercise of such options in accordance with the terms of the Stock
 Option Plan and the Option Agreements and (ii) certificates representing
 the Shares in the form of the specimen certificates examined by us have
 been manually signed by an authorized officer of the transfer agent and
 registrar for the Common Stock and registered by such transfer agent and
 registrar, such Shares will be duly and validly issued, fully paid and
 nonassessable (except as provided in Section 630 of the New York Business
 Corporation Law).

           We hereby consent to the filing of this opinion with the
 Commission as Exhibit 5 to the Registration Statement.  In giving such
 consent, we do not thereby admit that we are included in the category of
 persons whose consent is required under Section 7 of the Securities Act.


                                         Very truly yours,


                                         /s/ Skadden, Arps, Slate,
                                               Meagher & Flom LLP





                                                               EXHIBIT 23.1


                    CONSENT OF INDEPENDENT ACCOUNTANTS


We hereby consent to the incorporation by reference in this registration
statement on Form S-8 of our report, which is based in part on the report
of other auditors, dated February 5, 1999 relating to the financial
statements which appear in Regeneron Pharmaceuticals, Inc.'s Annual Report
on Form 10-K for the year ended December 31, 1998.


                                      /s/ PricewaterhouseCoopers LLP
                                      ------------------------------
                                        PricewaterhouseCoopers LLP


New York, New York
June 9, 1999




                                                              EXHIBIT 23.2


               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS


 We consent to the incorporation by reference in the Registration Statement
 on  Form S-8 pertaining to the Regeneron Pharmaceuticals, Inc. Amended and
 Restated 1990 Long Term Incentive Plan, of our report dated February 5,
 1999, with respect to the financial statements of Amgen-Regeneron Partners
 included in Regeneron Pharmaceuticals, Inc.'s Annual Report (Form 10-K) for
 the year ended December 31, 1998, filed with the Securities and Exchange
 Commission.


                                      /s/ Ernst and Young LLP
                                      ------------------------
                                      Ernst and Young LLP


 Los Angeles, California
 June 10, 1999