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Disclosure - Product Sales - Schedule of Net Product Sales (Details) link:presentationLink link:calculationLink link:definitionLink 0000046 - Disclosure - Product Sales - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000047 - Disclosure - Product Sales - Schedule of Concentration of Risk, by Risk Factor (Details) link:presentationLink link:calculationLink link:definitionLink 0000048 - Disclosure - Product Sales - Schedule of Sales Related Deductions Activity (Details) link:presentationLink link:calculationLink link:definitionLink 0000049 - Disclosure - Collaboration, License, and Other Agreements - Schedule of Collaboration Revenue Earned From Sanofi (Details) link:presentationLink link:calculationLink link:definitionLink 0000050 - Disclosure - Collaboration, License, and Other Agreements - Sanofi, Antibody Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000051 - Disclosure - Collaboration, License, and Other Agreements - Schedule of Accounts Receivable and Deferred Revenue Information, Antibody Collaboration (Details) link:presentationLink link:calculationLink link:definitionLink 0000052 - Disclosure - Collaboration, License, and Other Agreements - Sanofi, Immuno-Oncology Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000053 - Disclosure - Collaboration, License, and Other Agreements - Schedule of Accounts Receivable and Deferred Revenue Information, IO Collaboration (Details) link:presentationLink link:calculationLink link:definitionLink 0000054 - Disclosure - Collaboration, License, and Other Agreements - Bayer Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000055 - Disclosure - Collaboration, License, and Other Agreements - Schedule of Collaboration Revenue Earned From Bayer (Details) link:presentationLink link:calculationLink link:definitionLink 0000056 - Disclosure - Collaboration, License, and Other Agreements - Schedule of Contract Balances, Bayer Collaborative (Details) link:presentationLink link:calculationLink link:definitionLink 0000057 - Disclosure - Collaboration, License, and Other Agreements - Intellia Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000058 - Disclosure - Collaboration, License, and Other Agreements - U.S. Government Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000059 - Disclosure - Collaboration, License, and Other Agreements - Amounts Recognized in Statement of Operations with Roche (Details) link:presentationLink link:calculationLink link:definitionLink 0000060 - Disclosure - Collaboration, License, and Other Agreements - Schedule of Contract Balances, Roche Collaboration (Details) link:presentationLink link:calculationLink link:definitionLink 0000061 - Disclosure - Collaboration, License, and Other Agreements - Alnylam Narratives (Details) link:presentationLink link:calculationLink link:definitionLink 0000062 - Disclosure - Collaboration, License, and Other Agreements - Checkmate Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000063 - Disclosure - Collaboration, License, and Other Agreements - Teva Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000064 - Disclosure - Collaboration, License, and Other Agreements - Amounts Recognized in Statement of Operations with Teva (Details) link:presentationLink link:calculationLink link:definitionLink 0000065 - Disclosure - Collaboration, License, and Other Agreements - Schedule of Contract Balances, Teva Collaboration (Details) link:presentationLink link:calculationLink link:definitionLink 0000066 - Disclosure - Marketable Securities - Schedule of Investments in Available For Sale Debt Securities (Details) link:presentationLink link:calculationLink link:definitionLink 0000067 - Disclosure - Marketable Securities - Schedule of Debt Securities Based on Contractual Maturity Dates (Details) link:presentationLink link:calculationLink link:definitionLink 0000068 - Disclosure - Marketable Securities - Schedule of Fair Value and Unrealized Losses of Debt Securities (Details) link:presentationLink link:calculationLink link:definitionLink 0000069 - 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Disclosure - Commitments and Contingencies - Finance lease costs (Details) link:presentationLink link:calculationLink link:definitionLink 0000084 - Disclosure - Commitments and Contingencies - Other information related to finance lease (Details) link:presentationLink link:calculationLink link:definitionLink 0000085 - Disclosure - Commitments and Contingencies - Analysis of lease liability maturities (Details) link:presentationLink link:calculationLink link:definitionLink 0000085 - Disclosure - Commitments and Contingencies - Analysis of lease liability maturities (Details) link:presentationLink link:calculationLink link:definitionLink 0000086 - Disclosure - Commitments and Contingencies - Research Collaboration and Licensing Agreements Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000087 - Disclosure - Stockholders' Equity - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000088 - Disclosure - Stockholders' Equity - Schedule of Repurchased Shares (Details) link:presentationLink link:calculationLink link:definitionLink 0000089 - Disclosure - Long-Term Incentive Plans - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000090 - Disclosure - Long-Term Incentive Plans - Summary of transactions involving stock option awards (Details) link:presentationLink link:calculationLink link:definitionLink 0000091 - Disclosure - Long-Term Incentive Plans - Summary of weighted-average exercise prices and weighted-average grant-date fair values of options issued (Details) link:presentationLink link:calculationLink link:definitionLink 0000092 - Disclosure - Long-Term Incentive Plans - Summary of weighted-average values of assumptions used in computing fair value of option grants (Details) link:presentationLink link:calculationLink link:definitionLink 0000093 - Disclosure - Long-Term Incentive Plans - Summary of activity related to restricted stock awards (Details) link:presentationLink link:calculationLink link:definitionLink 0000094 - 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Disclosure - Statement of Cash Flows - Summary of Non-Cash Investing and Financing Activities (Details) link:presentationLink link:calculationLink link:definitionLink